Abstract

The electrochemical properties of triamcinolone acetonide on carbon-paste electrodes have been studied. By the cyclic voltammetry method it was revealed that this steroid is irreversibly reduced at a potential from -0.9 to -1.4 V, depending on the solution pH and the potential sweep rate, while an increase in the sweep rate results in a shift of the peak position to more negative potentials. The limiting stage of the process of reducing triamcinolone acetonide on carbon-paste electrodes is diffusion. The calibration graph was linear in the concentration range from 2 to 46 μmol/L, the detection limit was 1.5 μmol/L. The possibility of using differential pulse voltammetry on carbon-paste electrodes for the determination of the active substance content in ampoules of a suspension of Kenalog 40 was shown.

Keywords: triamcinolone acetonide, triamcinolone, glucocorticosteroid, carbon-paste electrodes, cyclic
voltammetry, differential pulse voltammetry

Article language: Rus