Abstract

In this work, the electro-catalytic oxidation of ibuprofen was studied using aluminum oxide supported on clay (Clay/Al₂O₃). The latter has been successfully prepared by impregnating aluminum particles in the clay by heat treatment. The electro-catalytic performances of Clay/Al₂O₃ for the oxidation of ibuprofen were studied using cyclic voltammetry (CV), chronoamperometry, and differential pulse voltammetry (DPV) in 0.1 mol L^-1 of the phosphate buffer (pH = 7). It has been shown that the proposed catalyst exhibits remarkably an electro-catalytic effect performance vis-a-vis the oxidation of ibuprofen. In addition, the peak oxidation currents depend linearly on the ibuprofen concentration in the wide ranges from 1.0·10^-3 mol L^-1 to 1.0·10^-6 mol L^-1 with a detection limit of 1.95·10^-8 mol L^-1 and response time of 30 second. Possible interferences were evaluated in 1.0·10^-5 mol L^-1 ibuprofen. The proposed catalyst also indicated suitable repeatability and stability. Besides, the proposed CPE-Clay/Al₂O₃ has been successfully applied for ibuprofen analysis in human blood with good recoveries.

Keywords: Ibuprofen, Clay, Al₂O₃, human blood, electrocatalysis

Article language: En