 |
METHODS AND OBJECTS OF CHEMICAL ANALYSIS
An international journal devoted to all aspects of analytical chemistry ISSN 2413-6166 (Online), ISSN 1991-0290 (Print) |
 |
| Ukr | En | ||
 
|
||
|
Development of a Sensitive Spectrophotometric Method for Determination of the Charge-Transfer Complex of Aripiprazole in Pharmaceutical Formulations: Spectrometric Characteristics and Analytical Applications |
|
|
* Corresponding authors
† Bezmialem Vakif University, Faculty of Pharmacy, Department of Analytical Chemistry, 34093, Istanbul,
Turkey; *e-mail: ddincel@bezmialem.edu.tr |
||
|
Methods Objects Chem. Anal., 2024, 19(4), p. 219-225 https://doi.org/10.17721/moca.2024.219-225 The article is distributed under open access Creative Commons Attribution License CC BY 4.0. |
||
Abstract
This study presents a simple, rapid, and accurate spectrophotometric method for the determination of Aripiprazole (ARP) in tablets. The determination procedure is based on the reaction of ARP with 7,7,8,8-tet racyanoquinodimethane (TCNQ), producing a colored product that was quantitated spectrophotometrically at 392 nm. Various variables affecting the reaction were optimized. The method exhibited a good linearity range with a correlation coefficient of 0.9994, observed as 0.25–3 μg/mL. The developed method was validated according to the International Council for Harmonisation (ICH) guidelines, assessing specificity, linearity, accuracy, precision, robustness, limit of detection (LOD), and limit of quantitation (LOQ). The formation of the CT-complex and the interaction sites were confirmed by elemental analysis, DSC, IR, and 1H NMR spectroscopy. The method was successfully applied to the determination of ARP in pharmaceutical preparation.
Keywords: schizophrenia, antipsychotics, aripiprazole, spectrophotometric method, pharmaceutical preparations
Article language: En
Publisher: Taras Shevchenko National University, Kiev Ukraine
(Analytical chemistry department at Taras Shevchenko
National University, 64 Vladimirskaya STR., Kiev, 01601 UKRAINE)
analysis@univ.kiev.ua,
www.univ.kiev.ua,
+380 (44) 2393444
The journal is indexed in SCOPUS and Web of Science
The journal website: www.moca.net.ua
The articles in this journal are licensed under
CC BY 4.0
